Research Infrastructure Programs (93.351)

National Institutes of Health

Opened 12 times since 2024. Usually posted in October, with deadlines in July and September.

Based on 12 recorded past opportunities. Opportunities under one Assistance Listing may cover different projects or funding cycles.

When might the next round open?

Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed): expected to open November 24, 2026, according to the current forecast.
National Biomedical Research Centers (P50 Clinical Trial Optional): expected to open November 25, 2026, according to the current forecast.
Research Resource for a National Swine Resource and Research Center (U42 Clinical Trial Not Allowed): expected to open November 25, 2026, according to the current forecast.
Small Instruments and Modern Equipment for Shared-use Biomedical Research Facilities and Resources (S15 Clinical Trial Not Allowed): expected to open July 27, 2027, according to the current forecast.
Testing Centers for Evaluation of Somatic Cell Genome Editing Approaches for Translational Applications (U42 Clinical Trial Not Allowed): expected to open November 25, 2027, according to the current forecast.
Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed): expected to open December 16, 2027, according to the current forecast.

Open now

Forecast opportunities are expected but are not accepting applications yet.

Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed)

Department of Health and Human Services $212K to $2.7M Small businesses eligible

Expected around Jan 25, 2027
National Biomedical Research Centers (P50 Clinical Trial Optional)

Department of Health and Human Services $8M to $11.4M Small businesses eligible

Expected around Jan 25, 2027
Research Resource for a National Swine Resource and Research Center (U42 Clinical Trial Not Allowed)

Department of Health and Human Services $961K to $1M Small businesses eligible

Expected around Jan 25, 2027
NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Apr 5, 2027
NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Apr 5, 2027
Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes May 7, 2027
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Jul 12, 2027
Successor-in-Interest (Type 6 Parent Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Jul 17, 2027
Small Instruments and Modern Equipment for Shared-use Biomedical Research Facilities and Resources (S15 Clinical Trial Not Allowed)

Department of Health and Human Services $25K to $350K Small businesses eligible

Expected around Sep 27, 2027
Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)

Department of Health and Human Services Up to $200K Small businesses eligible

Closes Jan 7, 2028
NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2028
Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)

Department of Health and Human Services Up to $375K Others (see eligibility details)

Closes Jan 7, 2028
Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Jan 7, 2028
Testing Centers for Evaluation of Somatic Cell Genome Editing Approaches for Translational Applications (U42 Clinical Trial Not Allowed)

Department of Health and Human Services $580K to $900K Small businesses eligible

Expected around Jan 25, 2028
Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)

Department of Health and Human Services $190K to $500K Small businesses eligible

Expected around Feb 16, 2028
Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)

Department of Health and Human Services Small businesses eligible

Closes May 4, 2028
Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35)

Department of Health and Human Services Small businesses eligible

Closes May 7, 2028
INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)

Department of Health and Human Services Up to $200K Small businesses eligible

Closes Jun 15, 2028
INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

Department of Health and Human Services Up to $500K Small businesses eligible

Closes Jun 15, 2028
Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)

Department of Health and Human Services $50K to $400K Small businesses eligible

Closes Jul 1, 2028
Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)

Department of Health and Human Services $300K to $5M Small businesses eligible

Closes Jul 1, 2028
Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Aug 25, 2028
Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Sep 26, 2028
Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

Department of Health and Human Services Small businesses eligible

Closes Sep 28, 2028
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Nov 30, 2028
Limited Competition: Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)

Department of Health and Human Services $25K to $250K Small businesses eligible

Closes Jan 26, 2029
NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Apr 5, 2029
SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes Apr 5, 2029
NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)

Department of Health and Human Services Small businesses eligible

Closes May 7, 2029

Past rounds

Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers (U42 Clinical Trial Not Allowed)

RFA-OD-25-012

Posted
December 5, 2025

Deadline
May 1, 2026

Award
Not listed
Development of Animal Models and Related Biological Materials for Down Syndrome Research (R21 Clinical Trial Not Allowed)

PAR-25-214

Posted
November 25, 2024

Deadline
January 7, 2026

Award
Up to $200K
Limited Competition: Small Grant Program for ORIP Special Emphasis Research Career Award (SERCA) K01 Recipients (R03 Clinical Trial Not Allowed)

PAR-25-176

Posted
November 18, 2024

Deadline
May 7, 2026

Award
Up to $75K
Early Stage Investigator HIV/AIDS Research Using Nonhuman Primate (NHP) Models (R21 Clinical Trial Not Allowed)

PAR-25-165

Posted
November 15, 2024

Deadline
September 7, 2025

Award
Not listed
Limited Competition: Basic Instrumentation Grant (BIG) Program (S10 Clinical Trial Not Allowed)

PAR-24-326

Posted
October 29, 2024

Deadline
July 16, 2026

Award
Not listed
Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)

PAR-24-265

Posted
October 29, 2024

Deadline
July 16, 2026

Award
Not listed
High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed)

PAR-24-264

Posted
October 29, 2024

Deadline
July 16, 2026

Award
Not listed
Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed)

PA-25-212

Posted
October 28, 2024

Deadline
January 31, 2025

Award
Not listed
Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01 Clinical Trial Not Allowed)

PAR-25-076

Posted
October 25, 2024

Deadline
September 7, 2025

Award
Up to $500K
Centers for Precision Disease Modeling (U54) (Clinical Trials Not Allowed)

PAR-24-305

Posted
October 4, 2024

Deadline
December 15, 2024

Award
Not listed
Administrative Supplements to Promote Diversity in Research and Development Small Businesses SBIR/STTR (Admin Supp Clinical Trial Not Allowed)

PA-24-255

Posted
September 10, 2024

Deadline
February 21, 2025

Award
Not listed
Research Resource for Human Organs and Tissues (U42 Clinical Trial Not Allowed)

PAR-24-258

Posted
August 26, 2024

Deadline
September 25, 2025

Award
Not listed

History from Grants.gov, checked October 24, 2026 at 10:38 AM CT.

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