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Department of Health and Human Services, National Institutes of Health

BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program - iBCP (RM1 Clinical Trial Not Allowed)

Who can apply

  • Independent school districts
  • City or township governments
  • County governments
  • Public and tribal housing authorities
  • Federally recognized tribal governments
  • Nonprofits with 501(c)(3) status
  • Tribal organizations
  • Nonprofits without 501(c)(3) status
  • State governments
  • Special district governments
  • Others (see eligibility details)
  • Small businesses
  • Public and state-controlled colleges
  • For-profit organizations (not small businesses)
  • Private colleges and universities

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

About this grant

This Notice of Funding Opportunity (NOFO) supports transdisciplinary research teams seeking to develop mechanistic, biologically grounded explanations of how neural circuits and their cellular building blocks give rise to central nervous system (CNS) function. Teams must integrate expertise spanning molecular and cellular through systems neuroscience, with strong collaboration between experimental and computational investigators, to bridge cells, circuits, and behavior in a unified framework that yields mechanistic insight.Applications must explicitly connect three core elements: (1) characterization of circuit components (e.g., cell types and/or connectivity); (2) measurement of dynamic circuit activity, incorporating in vivo CNS recordings at cellular and sub-second temporal resolution; and (3) analyses of a tractable behavior or functional output.To address this significant challenge in neuroscience, proposed studies are expected to leverage innovative conceptual or theoretical frameworks, predictive models, and/or cutting-edge approaches that unify these three levels of analysis and bridge experimental and computational components.Recipients are expected to participate in BRAIN consortia activities to identify standards of practice towards multi-level integration.

Who has won this before

Assistance Listing 93.173

2,362awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $1,247,170,603.49 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE$88,304,328Place of performance: MassachusettsStarted
  • YALE UNIV$67,501,043.13Place of performance: ConnecticutStarted
  • NEW YORK UNIVERSITY$64,342,478.99Place of performance: New YorkStarted
  • DUKE UNIVERSITY$57,255,199.04Place of performance: North CarolinaStarted
  • UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL$49,744,439Place of performance: North CarolinaStarted

Most awards went to Massachusetts, California, and New York, ranked by dollars obligated at the place of performance across all matching awards.

Past rounds of this program (93.173)

Checked .

Assistance Listing 93.213

769awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $352,703,712.59 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • BAYLOR COLLEGE OF MEDICINE$47,843,324Place of performance: TexasStarted
  • UNIVERSITY OF CALIFORNIA, LOS ANGELES$36,749,424.02Place of performance: CaliforniaStarted
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE$27,942,719Place of performance: MassachusettsStarted
  • WASHINGTON STATE UNIVERSITY$22,367,527Place of performance: WashingtonStarted
  • REGENTS OF THE UNIVERSITY OF MINNESOTA$21,646,919Place of performance: MinnesotaStarted

Most awards went to California, Massachusetts, and Illinois, ranked by dollars obligated at the place of performance across all matching awards.

Past rounds of this program (93.213)

Checked .

Assistance Listing 93.242

7,582awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $5,327,447,122.58 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL$976,983,003.37Place of performance: North CarolinaStarted
  • THE JOHNS HOPKINS UNIVERSITY$282,005,486.98Place of performance: MarylandStarted
  • RUTGERS, THE STATE UNIVERSITY$179,737,926.25Place of performance: New JerseyStarted
  • SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE$92,363,814Place of performance: CaliforniaStarted
  • ALLEN INSTITUTE$91,890,365Place of performance: WashingtonStarted

Most awards went to California, Massachusetts, and New York, ranked by dollars obligated at the place of performance across all matching awards.

Past rounds of this program (93.242)

Checked .

Assistance Listing 93.273

2,413awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $1,355,605,412.45 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK$131,608,116.12Place of performance: New YorkStarted
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE$88,304,328Place of performance: MassachusettsStarted
  • THE JOHNS HOPKINS UNIVERSITY$62,109,392.97Place of performance: MarylandStarted
  • TRUSTEES OF INDIANA UNIVERSITY$55,473,936.03Place of performance: IndianaStarted
  • UNIVERSITAT BERN$53,419,828.39State not reportedStarted

Most awards went to California, New York, and North Carolina, ranked by dollars obligated at the place of performance across all matching awards.

Past rounds of this program (93.273)

Checked .

Assistance Listing 93.279

5,816awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $4,508,283,988.86 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL$976,983,003.37Place of performance: North CarolinaStarted
  • FAMILY HEALTH INTERNATIONAL$719,372,574.71Place of performance: North CarolinaStarted
  • FRED HUTCHINSON CANCER CENTER$204,359,786.25Place of performance: WashingtonStarted
  • DUKE UNIVERSITY$200,640,187Place of performance: North CarolinaStarted
  • GEORGE WASHINGTON UNIVERSITY (THE)$155,482,197.57Place of performance: MarylandStarted

Most awards went to California, New York, and Massachusetts, ranked by dollars obligated at the place of performance across all matching awards.

Past rounds of this program (93.279)

Checked .

Assistance Listing 93.286

2,300awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $1,023,673,956.37 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • EMORY UNIVERSITY$94,181,647.04Place of performance: GeorgiaStarted
  • UNIVERSITY OF LOUISVILLE$56,118,180Place of performance: KentuckyStarted
  • LOUISIANA STATE UNIVERSITY$53,358,966Place of performance: LouisianaStarted
  • THE GENERAL HOSPITAL CORPORATION$49,163,442.85Place of performance: MassachusettsStarted
  • UNIVERSITY OF CALIFORNIA, LOS ANGELES$36,749,424.02Place of performance: CaliforniaStarted

Most awards went to Massachusetts, California, and New York, ranked by dollars obligated at the place of performance across all matching awards.

Past rounds of this program (93.286)

Checked .

Assistance Listing 93.372

425awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $218,315,217.53 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE$36,067,309Place of performance: MassachusettsStarted
  • NEW YORK UNIVERSITY$32,222,992Place of performance: New YorkStarted
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE$24,867,782Place of performance: MassachusettsStarted
  • ALLEN INSTITUTE$24,793,677Place of performance: WashingtonStarted
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE$18,658,648.34Place of performance: MassachusettsStarted

Most awards went to California, Massachusetts, and Washington, ranked by dollars obligated at the place of performance across all matching awards.

Checked .

Assistance Listing 93.853

9,993awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $5,623,053,837.81 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL$976,983,003.37Place of performance: North CarolinaStarted
  • MAYO CLINIC$102,150,671Place of performance: MinnesotaStarted
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE$88,304,328Place of performance: MassachusettsStarted
  • THE GENERAL HOSPITAL CORPORATION$75,437,657Place of performance: MassachusettsStarted
  • RESEARCH TRIANGLE INSTITUTE$72,701,366Place of performance: North CarolinaStarted

Most awards went to California, Massachusetts, and New York, ranked by dollars obligated at the place of performance across all matching awards.

Past rounds of this program (93.853)

Checked .

Assistance Listing 93.865

6,770awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $3,824,375,642.14 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • FRED HUTCHINSON CANCER CENTER$1,073,967,937.81Place of performance: WashingtonStarted
  • FAMILY HEALTH INTERNATIONAL$719,372,574.71Place of performance: North CarolinaStarted
  • THE JOHNS HOPKINS UNIVERSITY$282,005,486.98Place of performance: MarylandStarted
  • DUKE UNIVERSITY$200,640,187Place of performance: North CarolinaStarted
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE$155,556,396Place of performance: MassachusettsStarted

Most awards went to California, Massachusetts, and New York, ranked by dollars obligated at the place of performance across all matching awards.

Past rounds of this program (93.865)

Checked .

Assistance Listing 93.866

12,905awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $11,562,057,308.75 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL$976,983,003.37Place of performance: North CarolinaStarted
  • REGENTS OF THE UNIVERSITY OF MICHIGAN$463,372,200Place of performance: MichiganStarted
  • OREGON HEALTH & SCIENCE UNIVERSITY$203,025,735Place of performance: OregonStarted
  • UNIVERSITY OF WASHINGTON$201,841,608Place of performance: WashingtonStarted
  • NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC.$199,819,363Place of performance: CaliforniaStarted

Most awards went to California, New York, and Massachusetts, ranked by dollars obligated at the place of performance across all matching awards.

Past rounds of this program (93.866)

Checked .

Assistance Listing 93.867

3,576awards with funding activity in the last 3 completed federal fiscal years, 2024–2026 (October 1, 2023 to September 30, 2026). Total awarded during this period: $2,079,424,374.18 in net obligations (funding committed, less reductions).

These awards are for the Assistance Listing as a whole, which may cover multiple opportunities.

Largest recent recipients, ranked by total award amount. Amounts below may include funding outside this period; years are award start years.

  • JAEB CENTER FOR HEALTH RESEARCH FOUNDATION, INC.$80,395,801Place of performance: FloridaStarted
  • JAEB CENTER FOR HEALTH RESEARCH FOUNDATION, INC.$61,555,044Place of performance: FloridaStarted
  • GEORGETOWN UNIVERSITY$53,181,497Place of performance: District of ColumbiaStarted
  • THE JOHNS HOPKINS UNIVERSITY$51,825,661Place of performance: MarylandStarted
  • JACKSON LABORATORY$47,177,814.2Place of performance: MaineStarted

Most awards went to California, New York, and Massachusetts, ranked by dollars obligated at the place of performance across all matching awards.

Past rounds of this program (93.867)

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Award data from USAspending.gov.

Program history

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