Department of Health and Human Services, National Institutes of Health
HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
Who can apply
- Independent school districts
- State governments
- City or township governments
- Federally recognized tribal governments
- County governments
- Small businesses
- Private colleges and universities
- Public and tribal housing authorities
- Nonprofits without 501(c)(3) status
- Others (see eligibility details)
- Public and state-controlled colleges
- Nonprofits with 501(c)(3) status
- Special district governments
- Tribal organizations
- For-profit organizations (not small businesses)
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
About this grant
The NIH Helping to End Addiction Long-term® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.
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