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Department of Health and Human Services, National Institutes of Health

Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed)

Who can apply

  • For-profit organizations (not small businesses)
  • Others (see eligibility details)
  • Special district governments
  • Tribal organizations
  • Public and state-controlled colleges
  • Private colleges and universities
  • Nonprofits with 501(c)(3) status
  • State governments
  • Nonprofits without 501(c)(3) status
  • Independent school districts
  • County governments
  • Public and tribal housing authorities
  • Small businesses
  • City or township governments
  • Federally recognized tribal governments

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

About this grant

The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 of the SMaHT Genome Characterization Centers (GCCs) initiative. The SMaHT Stage 2 GCCs will determine the functional consequences of somatic mutations in healthy and clinically relevant tissue samples, the latter comprising patients whose phenotype is suspected to be driven by somatic mutations. This work will support the SMaHT Network's efforts to characterize somatic mosaicism and its role in human biology and disease.

Program history

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