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Department of Health and Human Services, National Institutes of Health

Mechanistic Evaluation of Therapeutic Targets derived from Treatable Traits to Improve CNS Outcomes in People with HIV (R21/R33 Clinical Trial Not Allowed)

Who can apply

  • Independent school districts
  • Tribal organizations
  • For-profit organizations (not small businesses)
  • Small businesses
  • Nonprofits with 501(c)(3) status
  • Private colleges and universities
  • Federally recognized tribal governments
  • County governments
  • Special district governments
  • Nonprofits without 501(c)(3) status
  • City or township governments
  • Others (see eligibility details)
  • Public and state-controlled colleges
  • Public and tribal housing authorities
  • State governments

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

About this grant

The purpose of this notice of funding opportunity (NOFO) is to identify modifiable mechanisms and therapeutic targets to address central nervous system (CNS) complications associated with human immunodeficiency virus (HIV). The initiative supports a phased research approach beginning with the identification of patient phenotypes characterized by convergent pathophysiological features, followed by the discovery and experimental validation of molecular mechanisms using innovative in-vitro and in-vivo models. The goal of this NOFO is to advance therapeutic target, and intervention discovery to address the multifactorial and heterogeneous nature of HIV-associated CNS dysfunction.

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